ISSN 2146-8346
 

Case Report 


"Olanzapine induced hypothermia: a rare case report"

Javed Ather Siddiqui, Shazia Farheen Qureshi, Abdullah Al Zahrani.

Abstract
ABSTRACT:
Introduction:
We report a case of 40-year old man who had a diagnose case of schizophrenia on olanzapine, had develop symptomatic hypothermia. The majority of documented cases involve short duration of hypothermia often less than 24 hours. Antipsychotics that are more potent antagonists at 5HT2 than at dopamine2 receptors appear more likely to cause hypothermia.
Objective:
Hypothermia is an adverse drug reaction of antipsychotic drug use. It is strong 5HT2 antagonistc characteristics which induced hypothermia, have been proposed. 55 percent of hypothermia reports are for atypical antipsychotics.
Case presentation:
A 40-year old man with schizophrenia who was being treated with a therapeutic dose of olanzapine presented with shivering, slurred speech, Confusion. He had a core temperature of 31.5 celsius. Electrocardiogram showed sinus bradycardia with Osborn waves or J waves. He didnít have any risk factors for developing hypothermia except the use of olanzapine. There was improvement in his clinical condition with reversal of electrocardiogram changes following gradual re-warming and withhold of olanzapine.
Conclusion:
Olanzapine induced hypothermia is rare and has been reported during initiation and increasing the dose or even in stable dose, but this case report raises the possibility of hypothermia even in patients who are on stable doses of olanzapine for a long period of time. Clinicians should consider the possibility of drug induced illness in hypothermic patients who are taking antipsychotics.

Key words: Hypothermia, Osborn waves, J waves, Temperature-dysregulation, Camel hump sign.


 
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How to Cite this Article
Pubmed Style

Siddiqui JA, Qureshi SF, Zahrani AA. "Olanzapine induced hypothermia: a rare case report". J Behav Health. 2016; 5(4): 191-193. doi:10.5455/jbh.20160727120938


Web Style

Siddiqui JA, Qureshi SF, Zahrani AA. "Olanzapine induced hypothermia: a rare case report". http://www.jbehavioralhealth.com/?mno=226845 [Access: October 21, 2018]. doi:10.5455/jbh.20160727120938


AMA (American Medical Association) Style

Siddiqui JA, Qureshi SF, Zahrani AA. "Olanzapine induced hypothermia: a rare case report". J Behav Health. 2016; 5(4): 191-193. doi:10.5455/jbh.20160727120938



Vancouver/ICMJE Style

Siddiqui JA, Qureshi SF, Zahrani AA. "Olanzapine induced hypothermia: a rare case report". J Behav Health. (2016), [cited October 21, 2018]; 5(4): 191-193. doi:10.5455/jbh.20160727120938



Harvard Style

Siddiqui, J. A., Qureshi, S. F. & Zahrani, A. A. (2016) "Olanzapine induced hypothermia: a rare case report". J Behav Health, 5 (4), 191-193. doi:10.5455/jbh.20160727120938



Turabian Style

Siddiqui, Javed Ather, Shazia Farheen Qureshi, and Abdullah Al Zahrani. 2016. "Olanzapine induced hypothermia: a rare case report". Journal of Behavioral Health, 5 (4), 191-193. doi:10.5455/jbh.20160727120938



Chicago Style

Siddiqui, Javed Ather, Shazia Farheen Qureshi, and Abdullah Al Zahrani. ""Olanzapine induced hypothermia: a rare case report"." Journal of Behavioral Health 5 (2016), 191-193. doi:10.5455/jbh.20160727120938



MLA (The Modern Language Association) Style

Siddiqui, Javed Ather, Shazia Farheen Qureshi, and Abdullah Al Zahrani. ""Olanzapine induced hypothermia: a rare case report"." Journal of Behavioral Health 5.4 (2016), 191-193. Print. doi:10.5455/jbh.20160727120938



APA (American Psychological Association) Style

Siddiqui, J. A., Qureshi, S. F. & Zahrani, A. A. (2016) "Olanzapine induced hypothermia: a rare case report". Journal of Behavioral Health, 5 (4), 191-193. doi:10.5455/jbh.20160727120938





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