ISSN 2146-8346
 

Original Research 


Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.

Arbind kumar choudhary, Sheeladevi Rathinasamy.

Cited by (2)

Abstract
More than 90 countries have given the artificial sweetener aspartame the green light to be used in thousands of food and beverage products. Two hundred times sweeter than sugar, aspartame allows food manufacturers to produce sweet foods they can market as “low calorie,” “diet,” or sugar-free,” appealing to hundreds of millions of consumers looking to cut sugar from their diets. Concern relating to the possible adverse effect has been raised due to aspartames metabolic components. Aspartame is rapidly and completely metabolized in humans and experimental animals to aspartic acid (40%), phenylalanine (50%) and methanol (10%). Methanol, a toxic metabolite is primarily metabolized by oxidation to formaldehyde and then to formate these processes are accompanied by the formation of superoxide anion and hydrogen peroxide. This study focus is to understand whether the oral administration of aspartame (40 mg/kg b.w) for 90 days, have any effect on membrane bound ATPase’s, and antioxidant status in spinal cord of rats. To mimic human methanol metabolism, folate deficient rats were used. After 90 days of aspartame administration, shows a significant change in membrane bound ATPase’s and antioxidant level. This study concludes that oral administration of aspartame (40mg/kg.bw) for longer duration may cause oxidative stress in spinal cord, which didn’t have any consequence on motor behavior, but may cause other neuronal complication because oxidative stress in spinal cord can’t be ignored.

Key words: Aspartame, ATPase’s, oxidative stress, motor behavior, spinal cord.


 
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This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. J Behav Health. 2014; 3(2): 107-111. doi:10.5455/jbh.20140606114825


Web Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. http://www.jbehavioralhealth.com/?mno=156976 [Access: August 19, 2019]. doi:10.5455/jbh.20140606114825


AMA (American Medical Association) Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. J Behav Health. 2014; 3(2): 107-111. doi:10.5455/jbh.20140606114825



Vancouver/ICMJE Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. J Behav Health. (2014), [cited August 19, 2019]; 3(2): 107-111. doi:10.5455/jbh.20140606114825



Harvard Style

Arbind kumar choudhary, Sheeladevi Rathinasamy (2014) Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. J Behav Health, 3 (2), 107-111. doi:10.5455/jbh.20140606114825



Turabian Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. 2014. Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. Journal of Behavioral Health, 3 (2), 107-111. doi:10.5455/jbh.20140606114825



Chicago Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. "Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.." Journal of Behavioral Health 3 (2014), 107-111. doi:10.5455/jbh.20140606114825



MLA (The Modern Language Association) Style

Arbind kumar choudhary, Sheeladevi Rathinasamy. "Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.." Journal of Behavioral Health 3.2 (2014), 107-111. Print. doi:10.5455/jbh.20140606114825



APA (American Psychological Association) Style

Arbind kumar choudhary, Sheeladevi Rathinasamy (2014) Effect of aspartame in spinal cord and its motor behavior in Wistar albino rats.. Journal of Behavioral Health, 3 (2), 107-111. doi:10.5455/jbh.20140606114825





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